The innovative Shimabukuro is dubbed as "The Jimi Hendrix of the ukulele," blending the sounds of a Hawaiian instrument with American jazz, rock, pop, soul, and even traditional Japanese music on his most recent album Gently Weeps.

After his performance, Conan said, "We've been doing this show a long time, ladies and gentlemen. That's one of my favorite things I've ever seen."

Check out Shimabukuro's official website [1] and watch the YouTube video to see him channel his inner George Harrison.